Tiny new oncogenes

New pituitary oncogenes.

Pituitary tumors are common monoclonal neoplasms which cause considerable morbidity and mortality. Several molecular events underlying pituitary tumorigenesis have been elucidated in recent years, but no tumor marker has clearly emerged which assists clinical and therapeutic decisions. Activating mutations and loss of inactivating mutations, together with hypothalamic hormones, circulating horm...

High-risk learning: acquiring new word vectors from tiny data

Distributional semantics models are known to struggle with small data. It is generally accepted that in order to learn ‘a good vector’ for a word, a model must have sufficient examples of its usage. This contradicts the fact that humans can guess the meaning of a word from a few occurrences only. In this paper, we show that a neural language model such as Word2Vec only necessitates minor modifi...

Tiny dancers

A vital step in growth factor-driven angiogenesis is the coordinated engagement of endothelial integrins with the extracellular matrix. The molecular mechanisms that partner growth factors and integrins are being elucidated, revealing an intricate interaction of surface receptors and their signaling pathways.

Oncogenes and anti-oncogenes in tumorigenesis.

Recent advances have led to the identification of cellular genes which are involved in the initiation and progression of tumorigenesis. The proto-oncogenes, which normally participate in the regulation of cell proliferation and differentiation, can become oncogenes through alterations in the regulation of their expression and/or their coding sequences. Their contribution to the tumorigenic phen...

Antarctic problems: tiny krill to usher in new resource era.